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1

Modest reductions in BACE1 activity significantly reduce beta-amyloid plaque load and neuroinflammation in a mouse model of Alzheimer's disease

Meilandt, William, Atwal, Jasvinder, Gadkar, Kapil, Hoyte, Kwame, Luk, Wilman, Lu, Yanmei, Watts, Ryan, Scearce-Levie, Kimberly

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 43 KB

english, 2013

2

Vkgetation analysis along a successional gradient from heath to oak forest

Mads Meilandt Serensen, Knud Tybirk

Journal:

Nordic Journal of Botany

Year:

2000

Language:

english

File:

PDF, 736 KB

english, 2000

3

P1-062: Tau reduction prevents epileptiform activity in a mouse model of Alzheimer's disease: Gene expression microarray analysis

Erik D. Roberson, William J. Meilandt, Jinghua Yao, Jong Yoo, Jeffrey L. Noebels, Lennart Mucke

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 57 KB

english, 2008

4

Enhancing antibody uptake in brain to target BACE1

Jasi Atwal, Joy Yu, Yin Zhang, Yongmei Chen, Cecilia Chiu, William Meilandt, Kimberly Scearce-Levie, Yanmei Lu, Margaret Kenrick, Saileta Prabhu, Yan Wu, Mark Dennis, Ryan Watts

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 58 KB

english, 2012

5

Role of BACE1 and BACE2 in the production of endogenous mouse Aß

William Meilandt, Jasvinder Atwal, Hilda Solanoy, Kwame Hoyte, Wil Luk, Yanmei Lu, Ryan Watts, Kimberly Scearce-Levie

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 53 KB

english, 2012

6

Role of Hippocampal CA3 -Opioid Receptors in Spatial Learning and Memory

Meilandt, W. J.

Journal:

Journal of Neuroscience

Year:

2004

Language:

english

File:

PDF, 815 KB

english, 2004

7

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

Couch, J. A., Yu, Y. J., Zhang, Y., Tarrant, J. M., Fuji, R. N., Meilandt, W. J., Solanoy, H., Tong, R. K., Hoyte, K., Luk, W., Lu, Y., Gadkar, K., Prabhu, S., Ordonia, B. A., Nguyen, Q., Lin, Y., Lin

Journal:

Science Translational Medicine

Year:

2013

Language:

english

File:

PDF, 748 KB

english, 2013

8

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid- Production in Vivo

Atwal, J. K., Chen, Y., Chiu, C., Mortensen, D. L., Meilandt, W. J., Liu, Y., Heise, C. E., Hoyte, K., Luk, W., Lu, Y., Peng, K., Wu, P., Rouge, L., Zhang, Y., Lazarus, R. A., Scearce-Levie, K., Wang,

Journal:

Science Translational Medicine

Year:

2011

Language:

english

File:

PDF, 1.11 MB

english, 2011

9

P4-314

Meilandt, William J., Wu, Tiffany, Yu, Gui-Qiu, Scearce-Levie, Kimberly, Mucke, Lennart

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 59 KB

english, 2006

10

Chronic GluN2B Antagonism Disrupts Behavior in Wild-Type Mice Without Protecting Against Synapse Loss or Memory Impairment in Alzheimer's Disease Mouse Models

Hanson, J. E., Meilandt, W. J., Gogineni, A., Reynen, P., Herrington, J., Weimer, R. M., Scearce-Levie, K., Zhou, Q.

Journal:

Journal of Neuroscience

Year:

2014

Language:

english

File:

PDF, 601 KB

english, 2014

11

GluN2B Antagonism Affects Interneurons and Leads to Immediate and Persistent Changes in Synaptic Plasticity, Oscillations, and Behavior

Hanson, Jesse E, Weber, Martin, Meilandt, William J, Wu, Tiffany, Luu, Tom, Deng, Lunbin, Shamloo, Mehrdad, Sheng, Morgan, Scearce-Levie, Kimberly, Zhou, Qiang

Journal:

Neuropsychopharmacology

Year:

2013

Language:

english

File:

PDF, 981 KB

english, 2013

12

Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic A Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice

Meilandt, W. J., Cisse, M., Ho, K., Wu, T., Esposito, L. A., Scearce-Levie, K., Cheng, I. H., Yu, G.-Q., Mucke, L.

Journal:

Journal of Neuroscience

Year:

2009

Language:

english

File:

PDF, 561 KB

english, 2009

13

A Death Receptor 6-Amyloid Precursor Protein Pathway Regulates Synapse Density in the Mature CNS But Does Not Contribute to Alzheimer's Disease-Related Pathophysiology in Murine Models

Kallop, D. Y., Meilandt, W. J., Gogineni, A., Easley-Neal, C., Wu, T., Jubb, A. M., Yaylaoglu, M., Shamloo, M., Tessier-Lavigne, M., Scearce-Levie, K., Weimer, R. M.

Journal:

Journal of Neuroscience

Year:

2014

Language:

english

File:

PDF, 2.98 MB

english, 2014

14

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

Yu, Y. J., Atwal, J. K., Zhang, Y., Tong, R. K., Wildsmith, K. R., Tan, C., Bien-Ly, N., Hersom, M., Maloney, J. A., Meilandt, W. J., Bumbaca, D., Gadkar, K., Hoyte, K., Luk, W., Lu, Y., Ernst, J. A.,

Journal:

Science Translational Medicine

Year:

2014

Language:

english

File:

PDF, 642 KB

english, 2014

15

Enkephalin Elevations Contribute to Neuronal and Behavioral Impairments in a Transgenic Mouse Model of Alzheimer's Disease

Meilandt, W. J., Yu, G.-Q., Chin, J., Roberson, E. D., Palop, J. J., Wu, T., Scearce-Levie, K., Mucke, L.

Journal:

Journal of Neuroscience

Year:

2008

Language:

english

File:

PDF, 731 KB

english, 2008

16

Characterization of a sensitive mouse Aβ40 PD biomarker assay for Alzheimer's disease drug development in wild-type mice

Lu, Yanmei, Hoyte, Kwame, Montgomery, William H, Luk, Wilman, He, Dongping, Meilandt, William J, Zuchero, Y Joy Yu, Atwal, Jasvinder K, Scearce-Levie, Kimberly, Watts, Ryan J, DeForge, Laura E

Journal:

Year:

2016

Language:

english

File:

PDF, 947 KB

english, 2016

17

WIDESPREAD BRAIN DISTRIBUTION AND ROBUST BACE1 INHIBITION FOLLOWING INTRACEREBROVENTRICULAR INFUSION OF ANTI-BACE1 IN NON-HUMAN PRIMATES

Bumbaca, Daniela, Bumbaca, Daniela, Wildsmith, Kristin, Fuji, Reina, Scearce-Levie, Kimberly, Maloney, Janice, Meilandt, William, Solanoy, Hilda, Lu, Yanmei, Peng, Kate, Wilson, Blair, Chan, Pamela, K

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 57 KB

english, 2014

18

Estradiol's effects on learning and neuronal morphology vary with route of administration.

Garza-Meilandt, Annette, Cantu, Rebecca E., Claiborne, Brenda J.

Journal:

Behavioral Neuroscience

Year:

2006

Language:

english

File:

PDF, 771 KB

english, 2006

19

BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats

Weber, Martin, Wu, Tiffany, Meilandt, William J., Dominguez, Sara L., Solanoy, Hilda O., Maloney, Janice A., Ngu, Hai, Baca, Miriam, Kung, Chung, Lima, Lisa, Earr, Timothy K., Fleck, Daniel, Shields,

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 1.18 MB

english, 2017

20

Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease

Le Pichon, Claire E., Meilandt, William J., Dominguez, Sara, Solanoy, Hilda, Lin, Han, Ngu, Hai, Gogineni, Alvin, Sengupta Ghosh, Arundhati, Jiang, Zhiyu, Lee, Seung-Hye, Maloney, Janice, Gandham, Vin

Journal:

Science Translational Medicine

Year:

2017

Language:

english

File:

PDF, 20.26 MB

english, 2017

21

Widespread brain distribution and activity following anti-BACE1 intracerebroventricular infusion in nonhuman primates

Bumbaca Yadav, Daniela, Maloney, Janice A, Wildsmith, Kristin R, Fuji, Reina N, Meilandt, William J, Solanoy, Hilda, Lu, Yanmei, Peng, Kun, Wilson, Blair, Chan, Pamela, Gadkar, Kapil, Kosky, Andrew, G

Journal:

British Journal of Pharmacology

Year:

2017

Language:

english

File:

PDF, 812 KB

english, 2017

22

Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer’s Disease

Patel, Snahel, Meilandt, William J., Erickson, Rebecca I., Chen, Jinhua, Deshmukh, Gauri, Estrada, Anthony A., Fuji, Reina N., Gibbons, Paul, Gustafson, Amy, Harris, Seth F., Imperio, Jose, Liu, Wendy

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 3.70 MB

english, 2017

23

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

Friedman, Brad A., Srinivasan, Karpagam, Ayalon, Gai, Meilandt, William J., Lin, Han, Huntley, Melanie A., Cao, Yi, Lee, Seung-Hye, Haddick, Patrick C.G., Ngu, Hai, Modrusan, Zora, Larson, Jessica L.,

Journal:

Year:

2018

Language:

english

File:

PDF, 6.79 MB

english, 2018

24

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

Dejanovic, Borislav, Huntley, Melanie A., De Mazière, Ann, Meilandt, William J., Wu, Tiffany, Srinivasan, Karpagam, Jiang, Zhiyu, Gandham, Vineela, Friedman, Brad A., Ngu, Hai, Foreman, Oded, Carano,

Journal:

Year:

2018

Language:

english

File:

PDF, 5.22 MB

english, 2018

25

Dysfunctional glucocorticoid receptor with a single point mutation ablates the CCAAT/enhancer binding protein-dependent growth suppression response in a steroid-resistant rat hepatoma cell variant

Ramos, Ross A., Meilandt, William J., Wang, Edward C., Firestone, Gary L.

Journal:

The FASEB Journal

Year:

1999

Language:

english

File:

PDF, 666 KB

english, 1999

26

Multi-Scale Imaging of Tissues and Organoid Models by Backscattered Electron Scanning Microscopy after Pre- and Post-Embedding Immuno-Labeling

Reichelt, Mike, Mandikian, Danielle, Lopez, Alejandro, Katakam, Anand K., Smith, Derek, Meilandt, William, Imperio, Jose, Sagolla, Meredith

Journal:

Microscopy and Microanalysis

Year:

2019

Language:

english

File:

PDF, 855 KB

english, 2019

27

Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ

Meilandt, William J., Maloney, Janice A., Imperio, Jose, Lalehzadeh, Guita, Earr, Tim, Crowell, Susan, Bainbridge, Travis W., Lu, Yanmei, Ernst, James A., Fuji, Reina N., Atwal, Jasvinder K.

Journal:

Alzheimer's Research & Therapy

Year:

2019

File:

PDF, 7.91 MB

2019

28

Trem2 deletion reduces late-stage amyloid plaque accumulation, elevates the AÎ²42:AÎ²40 ratio, and exacerbates axonal dystrophy and dendritic spine loss in the PS2APP Alzheimer's mouse model

Meilandt, William J., Ngu, Hai, Gogineni, Alvin, Lalehzadeh, Guita, Lee, Seung-Hye, Srinivasan, Karpagam, Imperio, Jose, Wu, Tiffany, Weber, Martin, Kruse, Agatha J., Stark, Kimberly L., Chan, Pamela,

Journal:

Journal of Neuroscience

Year:

2020

File:

PDF, 9.41 MB

2020

29

Inducible EphA4 knockout causes motor deficits in young mice and is not protective in the SOD1G93A mouse model of ALS

Dominguez, Sara L., Earr, Timothy, Dourado, Michelle, Ngu, Hai, Meilandt, William J., Hanson, Jesse E.

Journal:

Scientific Reports

Year:

2020

File:

PDF, 6.79 MB

2020